Site-2 proteases (S2P) belong to the M50 family of metalloproteases. which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP). Protease-dependent liberation of dormant transcription factors triggers diverse cellular responses. such as sterol regulation. https://www.roneverhart.com/Dudley-ASA-Thunder-ZN-Hycon-12-52-300-Softballs-4A-068Y/