The axon initial segment (AIS) is an essential neuronal compartment. It is usually where action potentials are initiated. Recent studies demonstrated that the AIS is a plastic structure that can be regulated by neuronal activity and by the activation of metabotropic receptors. https://www.jmannino.com/deal-alert-Sink-Front-Polymer-Tip-Out-Trays-with-Hinges-flash-find/