A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties. aiming at attaining better anti-inflammatory effect with a good safety profile. Bromo. fluoro. https://safeersappliancers.shop/product-category/bosch-kir24nsf0g-serie-2-a-f-built-in-larder-fridge-221-litres-white/