Abstract While first-generation. spike (S)-based COVID-19 vaccines were effective against early SARS-CoV-2 strains. the rapid evolution of novel Omicron subvariants have substantially reduced vaccine efficacy. As such. https://www.roneverhart.com/Craggy-Range-Sauvignon-Blanc-Te-Muna-Road-Vineyard-Martinborough-2022/